ABSTRACT
@#Objective To investigate the effect of scalp acupuncture on cerebral blood flow and gross motor function in children with spastic cerebral palsy. Methods From January to November, 2016, 79 children with spastic cerebral palsy were randomly divided into con-ventional group (n=40) and scalp acupuncture group (n=39). Both groups received conventional rehabilitation treatment, and the scalp acu-puncture group was given scalp acupuncture in addition, for five months. The systolic blood flow velocity (Vs), mean flow velocity of cere-bral artery (Vm) and vascular resistance index (RI) of anterior cerebral artery (ACA), middle cerebral artery (MCA) and posterior cerebral artery (PCA) before and after treatment were assessed with color transcranial Doppler ultrasound (TCD). The clinical effect was evaluated with the Gross Motor Function Classification System (GMFCS). Results Five cases dropped out during the follow-up, three cases in the con-ventional group and two cases in the scalp acupuncture group. There was no significant difference in all the indexes between two groups be-fore treatment (P>0.05). After treatment, the Vs and Vm of ACA, MCA and PCA improved (t>2.051, P<0.05), no improvement was found in the RI of ACA, MCA and PCA in the conventional group (t<1.1631, P>0.05), and they decreased in the scalp acupuncture group (t>2.659, P<0.05). After treatment, the Vs and Vm of ACA, MCA and PCA were higher in the scalp acupuncture group than in the conventional group (t>2.098, P<0.05), the RI of ACA was lower in the scalp acupuncture group than in the conventional group (t=2.375, P<0.05), and no signifi-cant difference was found in the RI of MCA and PCA between two groups (t<1.637, P>0.05). The total effective rate was higher in the scalp acupuncture group than in the conventional group (χ2=6.887, P<0.05). Conclusion Scalp acupuncture facilitates to increase the cerebral blood flow, decrease the vascular resistance, and improve gross motor function in children with spastic cerebral palsy.
ABSTRACT
BACKGROUND: The pattern of sustained release tablets can reduce medication frequency and prolong release time, which are both beneficial for a better therapeutic effect.OBJECTIVE: To prepare naproxen sustained release tablets and investigate the influence of their prescription on the dissolution in vitro.DESIGN, TIME AND SETTING: A repeated measurement was carried out in the laboratory of Shunde Polytechnic in September 2005.MATERIALS: Naproxen, acrylic resin Ⅱ, hydroxypropyl methyl cellulose(HPMC)and octadecanoic acid were all offered by Guangzhou Xingang Chemical Industry Co., Ltd. Alcohol was analytical pure.METHODS: With the orthogonal design, the prescription of naproxen sustained release tablets was screened out by simple factor analysis, consisting of 250g naproxen, 12.5g HPMC (K4M), alcohol, and 1.2g magnesium separate. Drug tab letting was performed with different materials (octadecanoic acid, HPMC, 20% acrylic resin II and polyvidone K30), different viscosities of HPMC (K4M, K15M and K100M), and different rigidities of HPMC (2, 4 and 6kg)at the same granularity and same pressure.MAIN OUTCOME MEASURES: The influences of different materials, different viscosities of HPMC and different rigidities of HPMC on the release were observed. The release rate and release effect of naproxen sustained release tablets were determined.RESULTS: In accordance with the standard of sustained release tablets, the release for 8 hours of the materials prepared with HPMC at K4M viscosity were satisfied. At the rigidity of 2, 4 and 6 kg, the higher pressure indicated the slower release. The naproxen sustained release tablets sh6wed a good zero order release within 12 hours after the preparation.CONCLUSION: The prepared naproxen sustained release tablets have achieved the satisfactory release outcome.